Gene

mvda

ID
ZDB-GENE-041114-127
Name
mevalonate (diphospho) decarboxylase a
Symbol
mvda Nomenclature History
Previous Names
  • zgc:100824 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Wong et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mvda Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Porokeratosis 7, multiple types 614714
Associated With mvda Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006204 GHMP kinase N-terminal domain
Domain IPR041431 Mvd1, C-terminal
Family IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
Family IPR029765 Diphosphomevalonate decarboxylase
Homologous_superfamily IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR036554 GHMP kinase, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Diphosphomevalonate decarboxylase Diphosphomevalonate/phosphomevalonate decarboxylase GHMP kinase, C-terminal domain superfamily GHMP kinase N-terminal domain Mvd1, C-terminal Ribosomal protein S5 domain 2-type fold Ribosomal protein S5 domain 2-type fold, subgroup
UniProtKB:Q5U403 400
UniProtKB:A0A0R4ICC6 400
UniProtKB:A0A0R4IS81 354
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations