Gene
odad1
- ID
- ZDB-GENE-041114-110
- Name
- outer dynein arm docking complex subunit 1
- Symbol
- odad1 Nomenclature History
- Previous Names
-
- ccdc114
- dynein intermediate chain (1)
- zgc:101737
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to be involved in cilium movement and outer dynein arm assembly. Located in axoneme. Is expressed in several structures, including Kupffer's vesicle; basal plate midbrain region; forerunner cell group; nervous system; and spinal cord neural tube. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to several human genes including ODAD1 (outer dynein arm docking complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101737 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8591 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 20 | Alliance | Ciliary dyskinesia, primary, 20 | 615067 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ODAD1, central coiled coil region | Outer dynein arm-docking/Coiled-coil domain-containing protein |
|---|---|---|---|
|
UniProtKB:Q5U3R2
|
566 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ccdc114-201
(1)
|
Ensembl | 2,204 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-222L21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101737 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007408 (1) | 1849 nt | ||
| Genomic | GenBank:AL954137 (2) | 222162 nt | ||
| Polypeptide | UniProtKB:Q5U3R2 (1) | 566 aa |
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Cai, W., He, S., Liang, X.F., Yuan, X. (2018) DNA Methylation of T1R1 Gene in the Vegetarian Adaptation of Grass Carp Ctenopharyngodon idella. Scientific Reports. 8:6934
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
- Jerber, J., Baas, D., Soulavie, F., Chhin, B., Cortier, E., Vesque, C., Thomas, J., and Durand, B. (2014) The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Human molecular genetics. 23(3):563-77
- Austin-Tse, C., Halbritter, J., Zariwala, M.A., Gilberti, R.M., Gee, H.Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J.R., Patel-King, R.S., Tritschler, D., Bower, R., O'Toole, E., Porath, J.D., Hurd, T.W., Chaki, M., Diaz, K.A., Kohl, S., Lovric, S., Hwang, D.Y., Braun, D.A., Schueler, M., Airik, R., Otto, E.A., Leigh, M.W., Noone, P.G., Carson, J.L., Davis, S.D., Pittman, J.E., Ferkol, T.W., Atkinson, J.J., Olivier, K.N., Sagel, S.D., Dell, S.D., Rosenfeld, M., Milla, C.E., Loges, N.T., Omran, H., Porter, M.E., King, S.M., Knowles, M.R., Drummond, I.A., and Hildebrandt, F. (2013) Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American journal of human genetics. 93(4):672-686
- Vij, S., Rink, J.C., Ho, H.K., Babu, D., Eitel, M., Narasimhan, V., Tiku, V., Westbrook, J., Schierwater, B., and Roy, S. (2012) Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program. PLoS Genetics. 8(11):e1003019
- Yu, X., Ng, C.P., Habacher, H., and Roy, S. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics. 40(12):1445-1453
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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