Gene
pacrg
- ID
- ZDB-GENE-041114-100
- Name
- PARK2 co-regulated
- Symbol
- pacrg Nomenclature History
- Previous Names
-
- zgc:101786
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Acts upstream of or within determination of left/right symmetry. Predicted to be active in cytosol; neuron projection; and vesicle. Is expressed in several structures, including Kupffer's vesicle; axis; forerunner cell group; nervous system; and pronephros. Orthologous to human PACRG (parkin coregulated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101786 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pacrg | Wang et al., 2022 | |
| CRISPR2-pacrg | Wang et al., 2022 | |
| CRISPR3-pacrg | Wang et al., 2022 | |
| MO1-pacrg | N/A | Liu et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | Parkin co-regulated protein |
|---|---|---|---|---|
| UniProtKB:Q5U3Q1 | InterPro | 232 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195A15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-210P22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-4G17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101786 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192238 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007398 (1) | 978 nt | ||
| Genomic | GenBank:BX936463 (1) | 232846 nt | ||
| Polypeptide | UniProtKB:Q5U3Q1 (1) | 232 aa |
- Wang, J., Thomas, H.R., Thompson, R.G., Waldrep, S.C., Fogerty, J., Song, P., Li, Z., Ma, Y., Santra, P., Hoover, J.D., Yeo, N.C., Drummond, I.A., Yoder, B.K., Amack, J.D., Perkins, B., Parant, J.M. (2022) Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants. Disease models & mechanisms. 15(12):
- Liu, C., Cao, R., Xu, Y., Li, T., Li, F., Chen, S., Xu, R., Sun, K. (2018) Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Genome Medicine. 10:40
- Thumberger, T., Hagenlocher, C., Tisler, M., Beyer, T., Tietze, N., Schweickert, A., Feistel, K., and Blum, M. (2012) Ciliary and non-ciliary expression and function of PACRG during vertebrate development. Cilia. 1(1):13
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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