Gene

col6a4a

ID

ZDB-GENE-041111-303

Name

collagen, type VI, alpha 4a

Symbol

col6a4a Nomenclature History

Previous Names

col6a4a (1)
col6a6
im:7152043 (1)
si:dkey-202m9.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within axonogenesis and muscle organ development. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Is expressed in several structures, including digestive system; musculature system; nervous system; spleen; and ventral mesenchyme. Orthologous to human COL6A6 (collagen type VI alpha 6 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152043 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Ramanoudjame et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col6a4a Human Ortholog

No data available

Associated With col6a4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR002223	Pancreatic trypsin inhibitor Kunitz domain
Family	IPR050525	Extracellular Matrix Assembly and Organization
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily
Homologous_superfamily	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Additional Resources	Length	Collagen triple helix repeat	Extracellular Matrix Assembly and Organization	Pancreatic trypsin inhibitor Kunitz domain	Pancreatic trypsin inhibitor Kunitz domain superfamily	Proteinase inhibitor I2, Kunitz, conserved site	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A
UniProtKB:A0AB32TBZ3	InterPro	2574

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	col6a4a-201 (1) Ensembl	Ensembl		8,669 nt	Select Tool ZFIN BLAST
mRNA	col6a4a-202 (1) Ensembl	Ensembl		5,445 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations