Gene

mlip

ID

ZDB-GENE-041111-277

Name

muscular LMNA-interacting protein

Symbol

mlip Nomenclature History

Previous Names

im:7151231
si:ch211-163p8.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Is expressed in heart; heart tube; and myotome. Orthologous to human MLIP (muscular LMNA interacting protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151231 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With mlip Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis	620138

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Associated With mlip Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR029331	Muscular LMNA-interacting protein

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Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B7S3	InterPro	1117
UniProtKB:A0A8M1Q1Z8	InterPro	317
UniProtKB:A0A8M3AYS2	InterPro	1118
UniProtKB:A0A8M9QNK8	InterPro	1081
UniProtKB:A0AB32T6J7	InterPro	450

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mlip-201 (1) Ensembl	Ensembl		3,298 nt	Select Tool ZFIN BLAST
mRNA	mlip-202 (1) Ensembl	Ensembl		724 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-344J23	CU571255
Contained in	BAC	CH211-163P8	CU104761	ZFIN Curated Data
Encodes	EST	IMAGE:7151231	CK688193	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009307054 (1)	3538 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU571255 (2)	80442 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M3AYS2 (1)	1118 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	MLIP	6	Ensembl:ENSG00000146147 Gene:90523 HGNC:21355 OMIM:614106	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Mlip	9	Ensembl:ENSMUSG00000032355 Gene:69642 MGI:1916892	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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