Gene
cenpf
- ID
- ZDB-GENE-041111-205
- Name
- centromere protein F
- Symbol
- cenpf Nomenclature History
- Previous Names
-
- im:7140452
- im:7144238
- im:7154719 (1)
- im:7156761
- si:ch211-152h14.2
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable dynein complex binding activity. Involved in heart looping; kidney development; and ventricular system development. Acts upstream of or within cilium assembly. Predicted to be active in chromosome, centromeric region; nucleus; and spindle pole. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144238 (1 image)
- IMAGE:7140452 (10 images)
- IMAGE:7156761 (1 image)
- IMAGE:7154719 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Waters et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10281 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12055 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12296 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23121 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa23122 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28887 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU | |
| sa28888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36461 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36462 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cenpf | N/A | Waters et al., 2015 |
| MO2-cenpf | N/A | Waters et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Stromme syndrome | Alliance | Stromme syndrome | 243605 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Centromere protein Cenp-F | Centromere protein Cenp-F, leucine-rich repeat-containing domain | Centromere protein Cenp-F, N-terminal | Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:F1Q7X5 | InterPro | 2708 | ||||
| UniProtKB:A0A286Y8J7 | InterPro | 2675 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-152H14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140452 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7144238 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7154719 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7156761 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002665215 (1) | 9162 nt | ||
| Genomic | GenBank:BX936381 (1) | 156270 nt | ||
| Polypeptide | UniProtKB:F1Q7X5 (1) | 2708 aa |
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Valcarce, D.G., Riesco, M.F., Cuesta-Martín, L., Esteve-Codina, A., Martínez-Vázquez, J.M., Robles, V. (2023) Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. BMC Biology. 21:7070
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yao, L., Chen, J., Wu, X., Jia, S., Meng, A. (2017) Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics. 26(21):4168-4180
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Waters, A.M., Asfahani, R., Carroll, P., Bicknell, L., Lescai, F., Bright, A., Chanudet, E., Brooks, A., Christou-Savina, S., Osman, G., Walsh, P., Bacchelli, C., Chapgier, A., Vernay, B., Bader, D.M., Deshpande, C., O' Sullivan, M., Ocaka, L., Stanescu, H., Stewart, H.S., Hildebrandt, F., Otto, E., Johnson, C.A., Szymanska, K., Katsanis, N., Davis, E., Kleta, R., Hubank, M., Doxsey, S., Jackson, A., Stupka, E., Winey, M., Beales, P.L. (2015) The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. Journal of Medical Genetics. 52:147-56
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