Gene
mylkb
- ID
- ZDB-GENE-041111-150
- Name
- myosin light chain kinase b
- Symbol
- mylkb Nomenclature History
- Previous Names
-
- im:7142009
- mlck1b (1)
- si:dkey-226n16.2
- unm_sa1486
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Tournoij et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 7 | 613780 |
| Megacystis-microcolon-intestinal hypoperistalsis syndrome 1 | 249210 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FDK2
|
966 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance