Gene
ces2b
- ID
- ZDB-GENE-041014-96
- Name
- carboxylesterase 2b
- Symbol
- ces2b Nomenclature History
- Previous Names
-
- si:ch211-93f2.1
- wu:fb62a02
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables cholinesterase activity. Is expressed in gut; intestinal bulb; and liver. Orthologous to several human genes including CES1P1 (carboxylesterase 1 pseudogene 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146435 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14596 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16141 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24706 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38108 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44336 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019826 | Carboxylesterase type B, active site |
| Conserved_site | IPR019819 | Carboxylesterase type B, conserved site |
| Domain | IPR002018 | Carboxylesterase, type B |
| Family | IPR050309 | Type-B Carboxylesterase/Lipase |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
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Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, active site | Carboxylesterase type B, conserved site | Type-B Carboxylesterase/Lipase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZ17
|
1611 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-100E23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-93F2 | ZFIN Curated Data | |
| Encodes | EST | fb62a02 | ||
| Encodes | EST | IMAGE:7146435 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021470705 (1) | 5050 nt | ||
| Genomic | GenBank:BX942839 (2) | 173570 nt | ||
| Polypeptide | UniProtKB:A0A8M9PZ17 (1) | 1611 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- According to ZDB-PUB-210305-10, neighbor-joining phylogenetic tree showed that the sequence of si:ch211-93f2.1 was dissimilar from cholinesterase across 26 species (Fig. 4d), indicating that BChE-like protein in zebrafish is an atypical cholinesterase and si:ch211-93f2.1 has a unique evolutionary origin.
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Tan, K.S., Zhang, Y., Liu, L., Li, S., Zou, X., Zeng, W., Cheng, G., Wang, D., Tan, W. (2021) Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 255:110590
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Liu, W., Zheng, Y. (2018) Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 243:1904-1911
- Zhang, C., Ellis, J.L., Yin, C. (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Disease models & mechanisms. 9(11):1383-1396
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Howarth, D.L., Yin, C., Yeh, K., and Sadler, K.C. (2013) Defining hepatic dysfunction parameters in two models of Fatty liver disease in zebrafish larvae. Zebrafish. 10(2):199-210
- Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508
- Passeri, M.J., Cinaroglu, A., Gao, C., and Sadler, K.C. (2009) Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (Baltimore, Md.). 49(2):443-452
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