Gene
ino80
- ID
- ZDB-GENE-041014-72
- Name
- INO80 complex ATPase subunit
- Symbol
- ino80 Nomenclature History
- Previous Names
-
- si:ch211-244p18.3
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity and histone binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Predicted to act upstream of or within DNA damage response and DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of Ino80 complex. Is expressed in hematopoietic multipotent progenitor cell. Orthologous to human INO80 (INO80 complex ATPase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ding et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shin et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kh36 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| sa765 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15927 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23725 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43459 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ino80 | Shin et al., 2021 | |
| MO1-ino80 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DBINO domain | DNA helicase INO80, DEAQ-box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | INO80/SWR1 chromatin remodeling helicase | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ARX1
|
1558 | |||||||||
|
UniProtKB:Q5SPB7
|
1552 | |||||||||
|
UniProtKB:A0A8M3B1Z5
|
1557 | |||||||||
|
UniProtKB:A0A8M3AZ14
|
1556 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244P18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-14A13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045119 (1) | 5814 nt | ||
| Genomic | GenBank:AL929049 (1) | 223182 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARX1 (1) | 1558 aa |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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