Gene
flvcr1
- ID
- ZDB-GENE-041014-359
- Name
- FLVCR choline and heme transporter 1
- Symbol
- flvcr1 Nomenclature History
- Previous Names
-
- si:ch211-147d7.6
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and heme transmembrane transporter activity. Acts upstream of or within erythrocyte differentiation and heme metabolic process. Predicted to be active in membrane and mitochondrion. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, absent speech, and hypotonia. Orthologous to human FLVCR1 (FLVCR choline and heme transporter 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Mercurio et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-flvcr1 | (2) | |
| CRISPR2-flvcr1 | (2) | |
| MO1-flvcr1 | N/A | (2) |
| MO2-flvcr1 | N/A | (2) |
| MO3-flvcr1 | N/A | Mercurio et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with microcephaly, absent speech, and hypotonia | Alliance | Neurodevelopmental disorder with microcephaly, absent speech, and hypotonia | 621060 |
| Retinopathy-sensory neuropathy syndrome | 609033 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Choline/ethanolamine transporter FLVCR1-2/SLC49-like | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q5RGT2
|
527 | ||||
|
UniProtKB:A0A8M2B7P0
|
525 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
flvcr1-201
(1)
|
Ensembl | 2,644 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147D7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025522 (1) | 1584 nt | ||
| Genomic | GenBank:BX664628 (1) | 101135 nt | ||
| Polypeptide | UniProtKB:Q5RGT2 (1) | 527 aa |
- Petrillo, S., De Giorgio, F., Bertino, F., Garello, F., Bitonto, V., Longo, D.L., Mercurio, S., Ammirata, G., Allocco, A.L., Fiorito, V., Chiabrando, D., Altruda, F., Terreno, E., Provero, P., Munaron, L., Genova, T., Nóvoa, A., Carlos, A.R., Cardoso, S., Mallo, M., Soares, M.P., Tolosano, E. (2023) Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis. Angiogenesis. 26(3):365-384
- Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900
- Yin, H.M., Yan, L.F., Liu, Q., Peng, Z., Zhang, C.Y., Xia, Y., Su, D., Gu, A.H., Zhou, Y. (2020) Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science advances. 6:eaay9466
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Lian, J., Chen, J., Wang, K., Zhao, L., Meng, P., Yang, L., Wei, J., Ma, N., Xu, J., Zhang, W., Zhang, Y. (2018) Alas1 is essential for neutrophil maturation in zebrafish. Haematologica. 103(11):1785-1795
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mercurio, S., Petrillo, S., Chiabrando, D., Bassi, Z.I., Gays, D., Camporeale, A., Vacaru, A., Miniscalco, B., Valperga, G., Silengo, L., Altruda, F., Baron, M.H., Santoro, M.M., Tolosano, E. (2015) The Heme Exporter Flvcr1 Regulates Expansion And Differentiation Of Committed Erythroid Progenitors By Controlling Intracellular Heme Accumulation. Haematologica. 100(6):720-9
- Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6
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