Gene

hmcn1

ID
ZDB-GENE-041014-322
Name
hemicentin 1
Symbol
hmcn1 Nomenclature History
Previous Names
  • nag
  • nagel (1)
  • nel (1)
  • si:ch211-169j21.3
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Involved in basement membrane organization and fin morphogenesis. Predicted to localize to extracellular region. Is expressed in several structures, including axis; epidermis; median fin fold; notochord; and tail bud. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Orthologous to human HMCN1 (hemicentin 1).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hmcn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 1 Alliance {Macular degeneration, age-related, 1} 603075
Associated With hmcn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR006605 G2 nidogen/fibulin G2F
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013106 Immunoglobulin V-set domain
Domain IPR026823 Complement Clr-like EGF domain
Homologous_superfamily IPR009017 Green fluorescent protein
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Domain Details Per Protein
Protein Length Complement Clr-like EGF domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site G2 nidogen/fibulin G2F Green fluorescent protein Growth factor receptor cysteine-rich domain superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily von Willebrand factor A-like domain superfamily
UniProtKB:U3JAR0 186
UniProtKB:F1QVQ2 5616
UniProtKB:F1R7R3 5614
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations