ZFIN is now using GRCz12tu for Genomic Data
Gene
igf2r
- ID
- ZDB-GENE-041014-300
- Name
- insulin-like growth factor 2 receptor
- Symbol
- igf2r Nomenclature History
- Previous Names
-
- CI-MPR (1)
- si:ch211-214g8.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable insulin-like growth factor binding activity. Predicted to be involved in protein targeting to lysosome. Predicted to be located in Golgi membrane and endosome membrane. Predicted to be active in late endosome; plasma membrane; and trans-Golgi network. Is expressed in nervous system; presumptive neural retina; and somite. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR044865 | MRH domain |
| Homologous_superfamily | IPR009011 | Mannose-6-phosphate receptor binding domain superfamily |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
| Repeat | IPR000479 | Cation-independent mannose-6-phosphate receptor repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation-independent mannose-6-phosphate receptor repeat | Fibronectin type II domain | Fibronectin type II domain superfamily | Kringle-like fold | Mannose-6-phosphate receptor binding domain superfamily | MRH domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PSQ1 | InterPro | 2408 | ||||||
| UniProtKB:Q2TTK0 | InterPro | 2459 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers