Gene
mysm1
- ID
- ZDB-GENE-041014-28
- Name
- Myb-like, SWIRM and MPN domains 1
- Symbol
- mysm1 Nomenclature History
- Previous Names
-
- im:7153144
- si:ch211-59d15.8
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable deubiquitinase activity; histone binding activity; and transcription coactivator activity. Acts upstream of or within cranial skeletal system development. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human MYSM1 (Myb like, SWIRM and MPN domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153144 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31039 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36976 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36977 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36978 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36979 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bone marrow failure syndrome 4 | 618116 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | JAB1/MPN/MOV34 metalloenzyme domain | JAMM/MPN+ metalloenzymes, peptidase M67A | MPN domain | Myb domain | SANT domain | SANT/Myb domain | SWIRM domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P2N0
|
828 | |||||||||
|
UniProtKB:Q5RGA4
|
822 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-215A11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-59D15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7153144 | Thisse et al., 2004 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001164029 (1) | 3661 nt | ||
| Genomic | GenBank:BX942841 (1) | 202032 nt | ||
| Polypeptide | UniProtKB:A0A8M9P2N0 (1) | 828 aa |
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Tse, W.K.F. (2017) Importance of deubiquitinases in zebrafish craniofacial development. Biochemical and Biophysical Research Communications. 487(4):813-819
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
1 - 4 of 4
Show