Gene

hgfa

ID
ZDB-GENE-041014-2
Name
hepatocyte growth factor a
Symbol
hgfa Nomenclature History
Previous Names
  • hgf1
  • si:dkey-146j3.2
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in cerebellar granule cell differentiation and neuron migration. Is expressed in several structures, including DEL; adaxial cell; axis; endodermal cell; and forebrain neural rod. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hgfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 39 Alliance Deafness, autosomal recessive 39 608265
Associated With hgfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR003609 PAN/Apple domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR024174 Hepatocyte growth factor/Macrophage stimulatory protein
Family IPR027284 Hepatocyte growth factor
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR038178 Kringle superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Hepatocyte growth factor Hepatocyte growth factor/Macrophage stimulatory protein Kringle Kringle, conserved site Kringle-like fold Kringle superfamily PAN/Apple domain Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain
UniProtKB:Q5RGG3 699
UniProtKB:A4IGA7 712
UniProtKB:Q5QD59 59
UniProtKB:F1REK1 712
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations