Gene

pak6b

ID
ZDB-GENE-041014-121
Name
p21 protein (Cdc42/Rac)-activated kinase 6b
Symbol
pak6b Nomenclature History
Previous Names
  • pak6 (1)
  • si:ch211-158b22.3
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including BUB1B-PAK6 (BUB1B-PAK6 readthrough).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pak6b Human Ortholog
No data available
Associated With pak6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000095 CRIB domain
Domain IPR000719 Protein kinase domain
Domain IPR033923 p21 activated kinase binding domain
Domain IPR035066 Serine/threonine-protein kinase PAK 6, catalytic domain
Family IPR050285 STE20 Serine/Threonine-Protein Kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily p21 activated kinase binding domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase PAK 6, catalytic domain STE20 Serine/Threonine-Protein Kinase
UniProtKB:A5PEY8 607
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pak6b-201 (1) Ensembl 1,824 nt
mRNA pak6b-202 (1) Ensembl 2,203 nt
mRNA pak6b-203 (1) Ensembl 451 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations