scgn

ID

ZDB-GENE-041010-82

Name

secretagogin, EF-hand calcium binding protein

Symbol

scgn Nomenclature History

Previous Names

zgc:100843

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium ion binding activity. Acts upstream of or within brain development and spinal cord motor neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Is expressed in brain; pancreas; pancreatic bud; and spinal cord. Orthologous to human SCGN (secretagogin, EF-hand calcium binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Qin et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scgn Human Ortholog

No data available

Associated With scgn Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	scgn^{zf3193/zf3193}	standard conditions	Liu et al., 2023
autism spectrum disorder	scgn^zf3193/+	standard conditions	Liu et al., 2023

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR035798	Secretagogin, EF-hand domain
Family	IPR051001	Calbindin Calcium-Binding
Homologous_superfamily	IPR011992	EF-hand domain pair