Gene

p4ha3

ID

ZDB-GENE-041010-4

Name

prolyl 4-hydroxylase, alpha polypeptide III

Symbol

p4ha3 Nomenclature History

Previous Names

si:dkey-260j18.3 (1)
WITHDRAWN: zgc:103728
zgc:103728

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alar plate midbrain region; liver; muscle; optic tectum; and yolk syncytial layer. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With p4ha3 Human Ortholog

No data available

Associated With p4ha3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR013547	Prolyl 4-hydroxylase alpha-subunit, N-terminal
Domain	IPR044862	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Family	IPR045054	Prolyl 4-hydroxylase
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily

Domain Details Per Protein

Protein	Length	Oxoglutarate/iron-dependent dioxygenase domain	Prolyl 4-hydroxylase	Prolyl 4-hydroxylase, alpha subunit	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	Prolyl 4-hydroxylase alpha-subunit, N-terminal	Tetratricopeptide-like helical domain superfamily
UniProtKB:A0A8M9PC84 InterPro	592
UniProtKB:A0A8M9P742 InterPro	616
UniProtKB:A0A8N7T7S6 InterPro	538
UniProtKB:A0A8M9PLE4 InterPro	364
UniProtKB:A0A8M3ASK1 InterPro	402

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	p4ha3-201 (1) Ensembl	Ensembl	1,737 nt	Select Tool ZFIN BLAST
mRNA	p4ha3-203 (1) Ensembl	Ensembl	2,964 nt	Select Tool ZFIN BLAST
ncRNA	p4ha3-002 (1) Ensembl	Ensembl	690 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations