Gene
mgst1.1
- ID
- ZDB-GENE-041010-30
- Name
- microsomal glutathione S-transferase 1.1
- Symbol
- mgst1.1 Nomenclature History
- Previous Names
-
- mgst1
- Mgst1b (1)
- zgc:101898
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable glutathione transferase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in brain; gill; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human MGST1 (microsomal glutathione S-transferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101898 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bräutigam et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024411Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Microsomal glutathione S-transferase 1-like |
|---|---|---|---|---|---|
| UniProtKB:Q5XJJ0 | InterPro | 154 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mgst1.1-201
(1)
|
Ensembl | 946 nt | ||
| mRNA |
mgst1.1-202
(1)
|
Ensembl | 862 nt | ||
| ncRNA |
mgst1.1-003
(1)
|
Ensembl | 888 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-281G7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101898 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005957 (1) | 1031 nt | ||
| Genomic | GenBank:AL954848 (1) | 170178 nt | ||
| Polypeptide | UniProtKB:Q5XJJ0 (1) | 154 aa |
- Zhang, J., Ye, Z.W., Bräutigam, L., Chakraborty, P., Luo, Z., Culpepper, J., Aslam, M., Zhang, L., Johansson, K., Haeggström, J.Z., Xu, J., Olsson, M., Townsend, D.M., Mehrotra, S., Morgenstern, R., Tew, K.D. (2023) A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression. The Journal of biological chemistry. 299(8):104920
- Yang, H., Huang, Y., Li, Z., Guo, Y., Li, S., Huang, H., Yang, X., Li, G., Chen, H. (2022) Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Animals : an open access journal from MDPI. 12(20):
- Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
- Qian, L., Zhang, J., Chen, X., Qi, S., Wu, P., Wang, C., Wang, C. (2019) Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Environmental pollution (Barking, Essex : 1987). 247:775-782
- Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. (2019) Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Chemosphere. 232:171-179
- Bräutigam, L., Zhang, J., Dreij, K., Spahiu, L., Holmgren, A., Abe, H., Tew, K.D., Townsend, D.M., Kelner, M.J., Morgenstern, R., Johansson, K. (2018) MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biology. 17:171-179
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Qi, S., Liu, W., Zheng, Y. (2018) Thifluzamide affects lipid metabolism in zebrafish (Danio reio). The Science of the total environment. 633:1227-1236
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cui, Y., Lv, S., Liu, J., Nie, S., Chen, J., Dong, Q., Huang, C., Yang, D. (2017) Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish. Human & Experimental Toxicology. 36(3):207-217
- Pradhan, A., Ivarsson, P., Ragnvaldsson, D., Berg, H., Jass, J., Olsson, P.E. (2017) Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. The Science of the total environment. 584-585:1138-1146
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