Gene
tars1
- ID
- ZDB-GENE-041010-218
- Name
- threonyl-tRNA synthetase 1
- Symbol
- tars1 Nomenclature History
- Previous Names
-
- tars
- wu:fb07c05
- wu:fb39c12
- zgc:92586 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable threonine-tRNA ligase activity. Acts upstream of or within branching involved in blood vessel morphogenesis and regulation of sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; optic vesicle; and segmental plate. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92586 (1 image)
- IMAGE:7136667 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq16 | Allele with one point mutation | Unknown | Missense | ENU | |
| rj36 | Allele with one point mutation | Exon 5 | Unknown | ENU | |
| sa9871 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17576 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31471 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| y58 | Allele with one point mutation | Unknown | Nonsynonymous, Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tars1 | Cao et al., 2016 | |
| MO1-tars1 | N/A | Mirando et al., 2015 |
| MO2-tars1 | N/A | (2) |
| MO3-tars1 | N/A | Jeong et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonphotosensitive trichothiodystrophy 7 | Alliance | Trichothiodystrophy 7, nonphotosensitive | 618546 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR004095 | TGS |
| Domain | IPR004154 | Anticodon-binding |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR012947 | Threonyl/alanyl tRNA synthetase, SAD |
| Domain | IPR033728 | Threonine-tRNA ligase catalytic core domain |
| Domain | IPR047246 | Threonine-tRNA ligase, class IIa, anticodon-binding domain |
| Family | IPR002320 | Threonine-tRNA ligase, class IIa |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR012676 | TGS-like |
| Homologous_superfamily | IPR018163 | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Anticodon-binding | Anticodon-binding domain superfamily | Beta-grasp domain superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | TGS | TGS-like | Threonine-tRNA ligase catalytic core domain | Threonine-tRNA ligase, class IIa | Threonine-tRNA ligase, class IIa, anticodon-binding domain | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily | Threonyl/alanyl tRNA synthetase, SAD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PXD7 | InterPro | 563 | |||||||||||||
| UniProtKB:A8KC60 | InterPro | 718 | |||||||||||||
| UniProtKB:Q5XIZ3 | InterPro | 624 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-15O14 | ZFIN Curated Data | |
| Encodes | EST | fb07c05 | ||
| Encodes | EST | fb39c12 | ||
| Encodes | EST | IMAGE:7136667 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92586 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174725 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122786 (1) | 2636 nt | ||
| Genomic | GenBank:BX950187 (2) | 160256 nt | ||
| Polypeptide | UniProtKB:A8KC60 (1) | 718 aa |
- Jin, B., Xie, L., Zhan, D., Zhou, L., Feng, Z., He, J., Qin, J., Zhao, C., Luo, L., Li, L. (2022) Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase. Development (Cambridge, England). 149(17)
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
- Jeong, S.J., Park, S., Nguyen, L.T., Hwang, J., Lee, E.Y., Giong, H.K., Lee, J.S., Yoon, I., Lee, J.H., Kim, J.H., Kim, H.K., Kim, D., Yang, W.S., Kim, S.Y., Lee, C.Y., Yu, K., Sonenberg, N., Kim, M.H., Kim, S. (2019) A threonyl-tRNA synthetase-mediated translation initiation machinery. Nature communications. 10:1357
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Waldron, A.L., Cahan, S.H., Franklyn, C.S., Ebert, A.M. (2017) A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. PLoS One. 12:e0185317
- Cao, Z., Wang, H., Mao, X., Luo, L. (2016) Noncanonical function of Threonyl-tRNA synthetase regulates Vascular Development in Zebrafish. Biochemical and Biophysical Research Communications. 473(1):67-72
- Castranova, D., Davis, A.E., Lo, B.D., Miller, M.F., Paukstelis, P.J., Swift, M.R., Pham, V.N., Torres-Vázquez, J., Bell, K., Shaw, K.M., Kamei, M., Weinstein, B.M. (2016) Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 36(4):655-62
- Wan, Y., Zhang, Q., Zhang, Z., Song, B., Wang, X., Zhang, Y., Jia, Q., Cheng, T., Zhu, X., Leung, A.Y., Yuan, W., Jia, H., Fang, X. (2016) Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. BMC Medical Genomics. 9:13
- Mirando, A.C., Fang, P., Williams, T.F., Baldor, L.C., Howe, A.K., Ebert, A.M., Wilkinson, B., Lounsbury, K.M., Guo, M., Francklyn, C.S. (2015) Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Scientific Reports. 5:13160
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