Gene
tars1
- ID
- ZDB-GENE-041010-218
- Name
- threonyl-tRNA synthetase 1
- Symbol
- tars1 Nomenclature History
- Previous Names
-
- tars
- wu:fb07c05
- wu:fb39c12
- zgc:92586 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable threonine-tRNA ligase activity. Acts upstream of or within branching involved in blood vessel morphogenesis; regulation of sprouting angiogenesis; and sprouting angiogenesis. Predicted to be located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; optic vesicle; and segmental plate. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92586 (1 image)
- IMAGE:7136667 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonphotosensitive trichothiodystrophy 7 | Alliance | Trichothiodystrophy 7, nonphotosensitive | 618546 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR004095 | TGS |
| Domain | IPR004154 | Anticodon-binding |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR012947 | Threonyl/alanyl tRNA synthetase, SAD |
| Domain | IPR033728 | Threonine-tRNA ligase catalytic core domain |
| Domain | IPR047246 | Threonine-tRNA ligase, class IIa, anticodon-binding domain |
| Family | IPR002320 | Threonine-tRNA ligase, class IIa |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR012676 | TGS-like |
| Homologous_superfamily | IPR018163 | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Anticodon-binding | Anticodon-binding domain superfamily | Beta-grasp domain superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | TGS | TGS-like | Threonine-tRNA ligase catalytic core domain | Threonine-tRNA ligase, class IIa | Threonine-tRNA ligase, class IIa, anticodon-binding domain | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily | Threonyl/alanyl tRNA synthetase, SAD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PXD7 | InterPro | 563 | |||||||||||||
| UniProtKB:A8KC60 | InterPro | 718 | |||||||||||||
| UniProtKB:Q5XIZ3 | InterPro | 624 |
Interactions and Pathways
No data available
Plasmids
No data available