Gene
mnat1
- ID
- ZDB-GENE-041010-203
- Name
- MNAT1 component of CDK activating kinase
- Symbol
- mnat1 Nomenclature History
- Previous Names
-
- zgc:101599
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; kinase activity; and metal ion binding activity. Predicted to be involved in DNA repair and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleotide-excision repair; phosphorylation; and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH holo complex. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101599 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR015877 | Cdk-activating kinase assembly factor MAT1, centre |
| Family | IPR004575 | Cdk-activating kinase assembly factor MAT1/Tfb3 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cdk-activating kinase assembly factor MAT1, centre | Cdk-activating kinase assembly factor MAT1/Tfb3 | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q5XJT0 | InterPro | 309 | |||||
| UniProtKB:A0A8M3BEN4 | InterPro | 309 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202M24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101599 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191263 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006100 (1) | 1247 nt | ||
| Genomic | GenBank:BX537123 (1) | 202967 nt | ||
| Polypeptide | UniProtKB:A0A8M3BEN4 (1) | 309 aa |
- Rauwerda, H., Wackers, P., Pagano, J.F., de Jong, M., Ensink, W., Dekker, R., Nehrdich, U., Spaink, H.P., Jonker, M., Breit, T.M. (2016) Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. PLoS One. 11:e0147151
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gómez-Marín, C., Tena, J.J., Acemel, R.D., López-Mayorga, M., Naranjo, S., de la Calle-Mustienes, E., Maeso, I., Beccari, L., Aneas, I., Vielmas, E., Bovolenta, P., Nobrega, M.A., Carvajal, J., Gómez-Skarmeta, J.L. (2015) Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proceedings of the National Academy of Sciences of the United States of America. 112(24):7542-7
- Silva, I.A., Cox, C.J., Leite, R.B., Cancela, M.L., Conceição, N. (2014) Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 172-173C:9-20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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