Gene

cited2

ID

ZDB-GENE-041010-141

Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Symbol

cited2 Nomenclature History

Previous Names

zgc:103418

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have transcription coactivator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Is expressed in several structures, including brain; immature eye; lens; optic primordium; and pharyngeal arch. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103418 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Santos et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cited2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
atrial heart septal defect 8	Alliance	Atrial septal defect 8	614433
ventricular septal defect	Alliance	Ventricular septal defect 2	614431

Associated With cited2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	AB + MO1-cited2 + MO2-cited2	standard conditions	Santos et al., 2019
congenital heart disease	AB + MO2-cited2	standard conditions	Santos et al., 2019