Gene

trappc6b

ID

ZDB-GENE-041010-122

Name

trafficking protein particle complex subunit 6B

Symbol

trappc6b Nomenclature History

Previous Names

zgc:103464 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within Golgi vesicle transport and nervous system development. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network and trans-Golgi network. Is expressed in central nervous system. Used to study syndromic intellectual disability. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy. Orthologous to human TRAPPC6B (trafficking protein particle complex subunit 6B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103464 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Marin-Valencia et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trappc6b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy	Alliance	Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy	617862

Associated With trappc6b Via Experimental Models

Human Disease	Fish	Conditions	Citations
syndromic intellectual disability	WT + MO1-trappc6b	standard conditions	Marin-Valencia et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007194	Transport protein particle (TRAPP) component
Family	IPR037992	TRAPP complex, Trs33 subunit
Homologous_superfamily	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily