Gene
amt
- ID
- ZDB-GENE-041010-114
- Name
- aminomethyltransferase
- Symbol
- amt Nomenclature History
- Previous Names
-
- fc31f04
- wu:fc31f04
- wu:fd44b12
- wu:fd54h12
- zgc:103483
- zgc:109741
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in glycine catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 2. Orthologous to human AMT (aminomethyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103483 (10 images)
- IMAGE:7157160 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
glycine encephalopathy 2 | Alliance | Glycine encephalopathy 2 | 620398 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006222 | Aminomethyltransferase, folate-binding domain |
Domain | IPR013977 | Aminomethyltransferase, C-terminal domain |
Family | IPR006223 | Glycine cleavage system T protein |
Family | IPR028896 | Aminomethyltransferase-like |
Homologous_superfamily | IPR027266 | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
Homologous_superfamily | IPR029043 | Glycine cleavage T-protein/YgfZ, C-terminal |
Domain Details Per Protein
Protein | Additional Resources | Length | Aminomethyltransferase, C-terminal domain | Aminomethyltransferase, folate-binding domain | Aminomethyltransferase-like | Glycine cleavage system T protein | Glycine cleavage T-protein/YgfZ, C-terminal | GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q5XJA4 | InterPro | 409 |
Interactions and Pathways
No data available
Plasmids
No data available