Gene
srcap
- ID
- ZDB-GENE-041008-127
- Name
- Snf2-related CREBBP activator protein
- Symbol
- srcap Nomenclature History
- Previous Names
-
- im:7137889
- im:7138264
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity and histone binding activity. Predicted to be involved in gene silencing and histone exchange. Predicted to localize to Swr1 complex. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137889 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Murphy et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Floating-Harbor syndrome | Alliance | Floating-Harbor syndrome | 136140 |
| Developmental delay, hypotonia, musculoskeletal defects, and behavioral abnormalities | 619595 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002034 | Alpha-isopropylmalate/homocitrate synthase, conserved site |
| Conserved_site | IPR017956 | AT hook, DNA-binding motif |
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014012 | Helicase/SANT-associated domain |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Family | IPR050520 | INO80/SWR1 chromatin remodeling helicase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-isopropylmalate/homocitrate synthase, conserved site | AT hook, DNA-binding motif | Helicase, C-terminal domain-like | Helicase/SANT-associated domain | Helicase superfamily 1/2, ATP-binding domain | INO80/SWR1 chromatin remodeling helicase | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B2C4
|
3873 | ||||||||||
|
UniProtKB:E7FAZ7
|
3917 | ||||||||||
|
UniProtKB:A0A8M2B358
|
3931 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance