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ZIRC
ZFIN ID: ZDB-GENE-041007-4
Gene Name: NOP10 ribonucleoprotein homolog (yeast)
Gene Symbol: nop10    Nomenclature History

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Previous Names: nola3, zgc:109956

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have box H/ACA snoRNA binding activity and telomerase RNA binding activity. Involved in primitive hemopoiesis and rRNA processing. Predicted to localize to the box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Used to study dyskeratosis congenita. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein).
Genome Resources: Alliance (1),  Gene:445391 (1),  Ensembl(GRCz11):ENSDARG00000104227 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109956]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2578Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025812Tg Transgenic Insertion Unknown Unknown DNA
    sa11074 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH nop10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive dyskeratosis congenita 1 Alliance Dyskeratosis congenita, autosomal recessive 1 224230
    DISEASE ASSOCIATED WITH nop10 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    dyskeratosis congenita nop10hi2578Tg/hi2578Tg standard conditions Pereboom et al., 2011
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primitive hemopoiesis (more)
    Cellular Component telomerase holoenzyme complex (more)
    Molecular Function snoRNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR007264 (1)
  • InterPro:IPR036756 (1)
  • Pfam:PF04135 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nop10-201 (1)    Ensembl 591
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nop10 No data available
    MARKER RELATIONSHIPS
    nop10 Encodes: [cDNA] MGC:109956 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003868 (1) 609 bp
    Genomic GenBank:HB964868 (1) 195 bp
    Polypeptide UniProtKB:Q6DRH5 (1) 64 aa
    Sequence Clusters UniGene:78253 (1)
    Sequence Information (all 20)
    ORTHOLOGY for nop10 ( Chr: 7 )
    CITATIONS (31)