Gene
ankef1a
- ID
- ZDB-GENE-041001-196
- Name
- ankyrin repeat and EF-hand domain containing 1a
- Symbol
- ankef1a Nomenclature History
- Previous Names
-
- ankrd5a
- si:dkey-20n10.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Is expressed in several structures, including digestive system; extension; forerunner cell group; otic vesicle; and pleuroperitoneal region. Orthologous to human ANKEF1 (ankyrin repeat and EF-hand domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Daniel et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ankef1a | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin Repeat and EF-hand Domain-containing | Ankyrin repeat-containing domain superfamily | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:Q5TZ64 | InterPro | 779 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ankef1a-201
(1)
|
Ensembl | 3,813 nt | ||
| mRNA |
ankef1a-202
(1)
|
Ensembl | 2,340 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20N10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025543 (1) | 2340 nt | ||
| Genomic | GenBank:BX465184 (1) | 139351 nt | ||
| Polypeptide | UniProtKB:Q5TZ64 (2) | 779 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Erickson, T., Biggers, W.P., Williams, K., Butland, S.E., Venuto, A. (2023) Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium. Journal of developmental biology. 11(2):
- Huang, J., Sun, L., Mennigen, J.A., Liu, Y., Liu, S., Zhang, M., Wang, Q., Tu, W. (2020) Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish: An emphasis on cilia disruption. Journal of hazardous materials. 409:124491
- Daniel, J.G., Panizzi, J.R. (2019) Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish. Gene expression patterns : GEP. 34:119069
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yuan, J.M., He, B.L., Yang, L.Y., Guo, C.J., Weng, S.P., Li, S.C., He, J.G. (2015) Interaction of Infectious Spleen and Kidney Necrosis Virus ORF119L with PINCH Leads to Dominant-Negative Inhibition of ILK and Cardiovascular Defects in Zebrafish. Journal of virology. 89(1):763-75
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