Gene
il17a/f3
- ID
- ZDB-GENE-041001-192
- Name
- interleukin 17a/f3
- Symbol
- il17a/f3 Nomenclature History
- Previous Names
-
- si:ch211-63o20.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within cellular response to lipopolysaccharide. Predicted to be located in extracellular space. Is expressed in gill and intestine. Human ortholog(s) of this gene implicated in several diseases, including Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); chronic mucocutaneous candidiasis; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A) and IL17F (interleukin 17F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Interleukin-17, chordata | Interleukin-17 family |
|---|---|---|---|---|---|
| UniProtKB:Q5TKT0 | InterPro | 162 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il17a/f3-201
(1)
|
Ensembl | 1,221 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-63O20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136319 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020790 (1) | 1242 nt | ||
| Genomic | GenBank:BX279523 (1) | 165073 nt | ||
| Polypeptide | UniProtKB:Q5TKT0 (1) | 162 aa |
No data available
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Laghi, V., Rezelj, V., Boucontet, L., Frétaud, M., Da Costa, B., Boudinot, P., Salinas, I., Lutfalla, G., Vignuzzi, M., Levraud, J.P. (2022) Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder. Frontiers in cellular and infection microbiology. 12:790851
- Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951
- Xie, J., Li, M., Ye, W., Shan, J., Zhao, X., Duan, Y., Liu, Y., Unger, B.H., Cheng, Y., Zhang, W., Wu, N., Xia, X.Q. (2021) Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis via α7nAchR-Mediated Anti-Inflammatory Effect Whilst Altering Microbiota Composition. Frontiers in immunology. 12:766845
- Diaz, O.E., Xue, S., Luo, X., Nava, J., Appelblom, A., Morales, R.A., Das, S., Villablanca, E.J. (2020) Retinoic acid induced cytokines are selectively modulated by Liver X Receptor activation in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 93:163-168
- Kaya, B., Doñas, C., Wuggenig, P., Diaz, O.E., Morales, R.A., Melhem, H., Swiss IBD. Cohort Investigators, Hernández, P.P., Kaymak, T., Das, S., Hruz, P., Franc, Y., Geier, F., Ayata, C.K., Villablanca, E.J., Niess, J.H. (2020) Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis. Cell Reports. 32:107979
- Coronado, M., Solis, C.J., Hernandez, P.P., Feijóo, C.G. (2019) Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile. Frontiers in immunology. 10:610
- Hernández, P.P., Strzelecka, P.M., Athanasiadis, E.I., Hall, D., Robalo, A.F., Collins, C.M., Boudinot, P., Levraud, J.P., Cvejic, A. (2018) Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 3(29):
- Jensen, H.M., Korbut, R., Kania, P.W., Buchmann, K. (2018) Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio). PLoS One. 13:e0200016
- Haarder, S., Kania, P.W., Holm, T.L., von Gersdorff Jørgensen, L., Buchmann, K. (2017) Effect of ES-products from Anisakis (Nematoda: Anisakidae) on experimentally induced colitis in adult zebrafish. Parasite immunology. 39(10)
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