ryr3

ID

ZDB-GENE-041001-165

Name

ryanodine receptor 3

Symbol

ryr3 Nomenclature History

Previous Names

ryrg (1)
si:ch211-189g6.1

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium ion binding activity; calmodulin binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in nervous system development; skeletal muscle fiber development; and smoothened signaling pathway. Predicted to be located in membrane and sarcoplasmic reticulum. Is expressed in Kupffer's vesicle; brain; musculature system; neurons; and somite. Human ortholog(s) of this gene implicated in congenital myopathy 20 and hepatocellular carcinoma. Orthologous to human RYR3 (ryanodine receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1589 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ryr3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital myopathy 20	Alliance	Congenital myopathy 20	620310

Associated With ryr3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000699	RIH domain
Domain	IPR001870	B30.2/SPRY domain
Domain	IPR002048	EF-hand domain
Domain	IPR003032	Ryanodine receptor Ryr
Domain	IPR003877	SPRY domain
Domain	IPR005821	Ion transport domain
Domain	IPR009460	Ryanodine Receptor TM 4-6
Domain	IPR013662	RyR/IP3R Homology associated domain
Domain	IPR014821	Inositol 1,4,5-trisphosphate/ryanodine receptor
Domain	IPR016093	MIR motif
Domain	IPR035761	Ryanodine receptor, SPRY domain 1
Domain	IPR035762	Ryanodine receptor, SPRY domain 3
Domain	IPR035764	Ryanodine receptor, SPRY domain 2
Domain	IPR048581	Ryanodine receptor, junctional solenoid domain
Family	IPR013333	Ryanodine receptor
Family	IPR015925	Ryanodine/Inositol 1,4,5-trisphosphate receptor
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR035910	RyR/IP3 receptor binding core, RIH domain superfamily
Homologous_superfamily	IPR036300	Mir domain superfamily
Homologous_superfamily	IPR043136	B30.2/SPRY domain superfamily