Gene

bach2b

ID

ZDB-GENE-041001-139

Name

BTB and CNC homology 1, basic leucine zipper transcription factor 2b

Symbol

bach2b Nomenclature History

Previous Names

bach2
si:dkeyp-4f12.1
si:dkeyp-4f12.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in head and trunk. Orthologous to human BACH2 (BTB domain and CNC homolog 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bach2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 60	Alliance	Immunodeficiency 60 and autoimmunity	618394

Associated With bach2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR004826	Basic leucine zipper domain, Maf-type
Domain	IPR004827	Basic-leucine zipper domain
Domain	IPR043321	BACH, basic leucine zipper (bZIP) domain
Family	IPR050457	Zinc finger and BTB domain-containing
Homologous_superfamily	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR046347	Basic-leucine zipper domain superfamily

Domain Details Per Protein

Protein	Length	BACH, basic leucine zipper (bZIP) domain	Basic-leucine zipper domain	Basic leucine zipper domain, Maf-type	Basic-leucine zipper domain superfamily	BTB/POZ domain	SKP1/BTB/POZ domain superfamily	Transcription factor, Skn-1-like, DNA-binding domain superfamily	Zinc finger and BTB domain-containing
UniProtKB:Q5RIW6 InterPro	823
UniProtKB:A0A8N7UQL1 InterPro	797

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	bach2b-201 (1) Ensembl	Ensembl	4,693 nt	Select Tool ZFIN BLAST
mRNA	bach2b-204 (1) Ensembl	Ensembl	2,322 nt	Select Tool ZFIN BLAST
ncRNA	bach2b-002 (1) Ensembl	Ensembl	543 nt	Select Tool ZFIN BLAST
ncRNA	bach2b-003 (1) Ensembl	Ensembl	540 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations