Gene
irf4b
- ID
- ZDB-GENE-041001-131
- Name
- interferon regulatory factor 4b
- Symbol
- irf4b Nomenclature History
- Previous Names
-
- si:dkey-25e12.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including axis; chordo neural hinge; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1640 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 131 | Alliance | Immunodeficiency 131 | 621097 |
| [Skin/hair/eye pigmentation, variation in, 8] | 611724 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PTA5 | InterPro | 433 | |||||||
| UniProtKB:A0AB32TE93 | InterPro | 431 |
Interactions and Pathways
No data available
Plasmids
No data available