ZFIN is now using GRCz12tu for Genomic Data
Gene
tmem251
- ID
- ZDB-GENE-041001-121
- Name
- transmembrane protein 251
- Symbol
- tmem251 Nomenclature History
- Previous Names
-
- gcaf (1)
- si:dkeyp-55f12.4
- zgc:112233
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in lysosome organization and regulation of vesicle-mediated transport. Predicted to be located in Golgi apparatus. Used to study mucolipidosis. Orthologous to human LYSET (lysosomal enzyme trafficking factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146490 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dysostosis multiplex, Ain-Naz type | 619345 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| mucolipidosis | WT + CRISPR1-tmem251 + CRISPR2-tmem251 + CRISPR3-tmem251 + CRISPR4-tmem251 | standard conditions | Zhang et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028024 | Lysosomal enzyme trafficking factor |
Domain Details Per Protein
| Protein | Additional Resources | Length | Lysosomal enzyme trafficking factor |
|---|---|---|---|
| UniProtKB:Q5TZA3 | InterPro | 142 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tmem251-201
(1)
|
Ensembl | 1,949 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers