Gene
gsx2
- ID
- ZDB-GENE-041001-114
- Name
- GS homeobox 2
- Symbol
- gsx2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within neuron development. Predicted to be active in nucleus. Is expressed in brain; forebrain neural rod; and spinal cord. Orthologous to human GSX2 (GS homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nub32 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| nub33 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| nub123Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| y691 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| y692 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diencephalic-mesencephalic junction dysplasia syndrome 2 | 618646 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GS homeobox 1/2 | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1RMA3 | InterPro | 242 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(gsx2:GFP) |
|
| 1 | (2) | |
| TgBAC(gsx2:LOXP-Tomato-LOXP-GFP) |
|
| 1 | (3) | |
| Tg(UAS-hsp70l:gsx2-AVI-2A-Eco.BirA-2A-mCherry,myl7:mCherry) |
| 1 | Itoh et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97C6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136270 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191505 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025512 (1) | 1292 nt | ||
| Genomic | GenBank:BX276097 (2) | 216655 nt | ||
| Polypeptide | UniProtKB:Q1RMA3 (1) | 242 aa |
- Coltogirone, R.A., Sherfinski, E.I., Dobler, Z.A., Peterson, S.N., Andlinger, A.R., Fadel, L.C., Patrick, R.L., Bergeron, S.A. (2022) Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):377-399
- Hageter, J., Waalkes, M., Starkey, J., Copeland, H., Price, H., Bays, L., Showman, C., Laverty, S., Bergeron, S.A., Horstick, E.J. (2021) Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish. Frontiers in behavioral neuroscience. 15:777778
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Itoh, T., Takeuchi, M., Sakagami, M., Asakawa, K., Sumiyama, K., Kawakami, K., Shimizu, T., Hibi, M. (2020) Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development (Cambridge, England). 147(19):
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14
- Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., Foucher, I. (2014) Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells. Developmental Cell. 30(2):123-36
- Satou, C., Kimura, Y., Hirata, H., Suster, M.L., Kawakami, K., and Higashijima, S. (2013) Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development (Cambridge, England). 140(18):3927-3931
- Wolf, A., and Ryu, S. (2013) Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development (Cambridge, England). 140(8):1762-1773
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