Gene
hsd17b2
- ID
- ZDB-GENE-040928-1
- Name
- hydroxysteroid (17-beta) dehydrogenase 2
- Symbol
- hsd17b2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable steroid dehydrogenase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in brain; heart; integument; pleuroperitoneal region; and trunk musculature. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2).
- Genome Resources
- Note
-
Mindnich et al. Steroid Biochem. Mol. Biol. 103(1): 35-43 suggest this may be a pseudogene.
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAC5 | InterPro | 381 | |||
| UniProtKB:Q1PLL0 | InterPro | 358 | |||
| UniProtKB:A0AB32TKP2 | InterPro | 306 |
1 - 3 of 3
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd17b2-201
(1)
|
Ensembl | 1,144 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-147D22 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-420A4 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140507 | Thisse et al., 2004 |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040188 (1) | 1077 nt | ||
| Genomic | GenBank:CU181895 (1) | 65370 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAC5 (1) | 381 aa |
- Xiao, L., Guo, Y., Wang, D., Zhao, M., Hou, X., Li, S., Lin, H., Zhang, Y. (2020) Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Frontiers in genetics. 11:161
- Shi, W.J., Ma, D.D., Jiang, Y.X., Xie, L., Zhang, J.N., Huang, G.Y., Chen, H.X., Hou, L.P., Liu, Y.S., Ying, G.G. (2019) Medroxyprogesterone acetate affects sex differentiation and spermatogenesis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 212:70-76
- Liang, Y.Q., Huang, G.Y., Lin, Z., Li, J., Yang, J.W., Zhong, L.Y., Ying, G.G. (2018) Reproductive effects of synthetic progestin norgestrel in zebrafish (Danio rerio). Chemosphere. 190:17-24
- Shi, W.J., Hu, L.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Xie, L., Ying, G.G. (2018) Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio). Chemosphere. 216:725-732
- Shi, W.J., Ying, G.G., Huang, G.Y., Liang, Y.Q., Hu, L.X., Zhao, J.L., Zhang, J.N. (2017) Transcriptional and Biochemical Alterations in Zebrafish Eleuthero-Embryos (Danio rerio) After Exposure to Synthetic Progestogen Dydrogesterone. Bulletin of environmental contamination and toxicology. 99(1):39-45
- Tan, T., Yu, R.M.K., Wu, R.S.S., Kong, R.Y.C. (2017) Overexpression and Knockdown of Hypoxia-Inducible Factor 1 Disrupt the Expression of Steroidogenic Enzyme Genes and Early Embryonic Development in Zebrafish. Gene regulation and systems biology. 11:1177625017713193
- Yan, Y.L., Desvignes, T., BreMiller, R., Wilson, C., Dillon, D., High, S., Draper, B., Buck, C.L., Postlethwait, J. (2017) The gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(11):925-945
- Filby, A.L., Paull, G.C., Searle, F., Ortiz-Zarragoitia, M., and Tyler, C.R. (2012) Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environmental science & technology. 46(6):3472-3479
- Yu, R.M., Chu, D.L., Tan, T.F., Li, V.W., Chan, A.K., Giesy, J.P., Cheng, S.H., Wu, R., and Kong, R. (2012) Leptin-mediated modulation of steroidogenic gene expression in hypoxic zebrafish embryos: Implications for the disruption of sex steroids. Environmental science & technology. 46(16):9112-9119
- Mindnich, R., Hrabe de Angelis, M., and Adamski, J. (2007) Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. The Journal of steroid biochemistry and molecular biology. 103(1):35-43
1 - 10 of 11
Show