Gene
ttr
- ID
- ZDB-GENE-040927-14
- Name
- transthyretin (prealbumin, amyloidosis type I)
- Symbol
- ttr Nomenclature History
- Previous Names
-
- zgc:103583
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have hormone activity and thyroid hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Is expressed in liver. Orthologous to human TTR (transthyretin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103583 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carpal tunnel syndrome 1 | Alliance | Carpal tunnel syndrome, familial | 115430 |
| dystransthyretinemic hyperthyroxinemia | Alliance | [Dystransthyretinemic hyperthyroxinemia] | 145680 |
| transthyretin amyloidosis | Alliance | Amyloidosis, hereditary, transthyretin-related | 105210 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transthyretin/hydroxyisourate hydrolase | Transthyretin/hydroxyisourate hydrolase domain | Transthyretin/hydroxyisourate hydrolase domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AW12
|
87 | |||
|
UniProtKB:B8JLL8
|
149 |
Interactions and Pathways
No data available
Plasmids
No data available