Gene
clxn
- ID
- ZDB-GENE-040914-40
- Name
- calaxin
- Symbol
- clxn Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Involved in cilium movement. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human CLXN (calaxin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911536 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sasaki et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ja201 | Allele with one insertion | Unknown | Premature Stop | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 53 | 620642 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Recoverin family |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LWZ0 | InterPro | 210 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
efcab1-202
(1)
|
Ensembl | 602 nt | ||
| mRNA |
efcab1-201
(1)
|
Ensembl | 771 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:clxn) |
|
| 1 | Morikawa et al., 2024 | |
| Tg(actb2:clxn_E130A) |
|
| 1 | Morikawa et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173P18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6911536 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:198200 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198202 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044860 (1) | 757 nt | ||
| Genomic | GenBank:BX510986 (1) | 157245 nt | ||
| Polypeptide | UniProtKB:Q1LWZ0 (1) | 210 aa |
- Morikawa, M., Yamaguchi, H., Kikkawa, M. (2024) Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm. Life science alliance. 7(9):
- Yamaguchi, H., Morikawa, M., Kikkawa, M. (2023) Calaxin stabilizes the docking of outer arm dyneins onto ciliary doublet microtubule in vertebrates. eLIFE. 12:
- Sasaki, K., Shiba, K., Nakamura, A., Kawano, N., Satouh, Y., Yamaguchi, H., Morikawa, M., Shibata, D., Yanase, R., Jokura, K., Nomura, M., Miyado, M., Takada, S., Ueno, H., Nonaka, S., Baba, T., Ikawa, M., Kikkawa, M., Miyado, K., Inaba, K. (2019) Calaxin is required for cilia-driven determination of vertebrate laterality. Communications biology. 2:226
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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