Gene
mast3a
- ID
- ZDB-GENE-040914-35
- Name
- microtubule associated serine/threonine kinase 3a
- Symbol
- mast3a Nomenclature History
- Previous Names
-
- mast3
- im:6911368
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within midbrain morphogenesis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911368 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 108 | Alliance | Developmental and epileptic encephalopathy 108 | 620115 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR015022 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain |
| Domain | IPR037711 | Microtubule-associated serine/threonine-protein kinase, catalytic domain |
| Domain | IPR041489 | PDZ domain 6 |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023142 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Microtubule-associated serine/threonine-protein kinase, catalytic domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily | PDZ domain | PDZ domain 6 | PDZ superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QZB3 | InterPro | 1295 | |||||||||||
| UniProtKB:A0A8M9PPY9 | InterPro | 1355 | |||||||||||
| UniProtKB:A0A8M9PXC1 | InterPro | 1351 | |||||||||||
| UniProtKB:A0A8M9Q0N6 | InterPro | 1354 | |||||||||||
| UniProtKB:A0A8M9PSZ3 | InterPro | 1318 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance