adprs

ID

ZDB-GENE-040912-85

Name

ADP-ribosylserine hydrolase

Symbol

adprs Nomenclature History

Previous Names

adprhl2
fj36e06 (1)
wu:fj36e06 (1)
zgc:92867 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair; negative regulation of necroptotic process; and peptidyl-serine ADP-deribosylation. Predicted to be located in site of DNA damage. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7143915 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adprs Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
stress-induced childhood-onset neurodegeneration with variable ataxia and seizures	Alliance	Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures	618170

Associated With adprs Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005502	ADP-ribosylation/Crystallin J1
Family	IPR050792	ADP-ribosylglycohydrolase
Homologous_superfamily	IPR036705	ADP-ribosylation/Crystallin J1 superfamily