Gene

pon1

ID

ZDB-GENE-040912-6

Name

paraoxonase 1

Symbol

pon1 Nomenclature History

Previous Names

zgc:91887

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have arylesterase activity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including PON1 (paraoxonase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6908182 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pon1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Coronary artery disease, susceptibility to}
		{Coronary artery spasm 2, susceptibility to}
		{Microvascular complications of diabetes 5}	612633
		{Organophosphate poisoning, sensitivity to}

Associated With pon1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002640	Arylesterase
Family	IPR051288	Serum paraoxonase/arylesterase
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR011045	Nitrous oxide reductase, N-terminal