Gene
coq5
- ID
- ZDB-GENE-040912-5
- Name
- coenzyme Q5, methyltransferase
- Symbol
- coq5 Nomenclature History
- Previous Names
-
- zgc:92445 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10797 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary coenzyme Q10 deficiency 9 | Alliance | ?Coenzyme Q10 deficiency, primary, 9 | 619028 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | S-adenosyl-L-methionine-dependent methyltransferase superfamily | UbiE/COQ5 methyltransferase | UbiE/COQ5 methyltransferase, conserved site |
|---|---|---|---|---|---|
| UniProtKB:Q66L51 | InterPro | 327 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-7C9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92445 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004541 (1) | 1570 nt | ||
| Genomic | GenBank:CT737139 (2) | 159336 nt | ||
| Polypeptide | UniProtKB:Q66L51 (1) | 327 aa |
- Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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