Gene

gle1

ID
ZDB-GENE-040831-4
Name
GLE1 RNA export mediator
Symbol
gle1 Nomenclature History
Previous Names
  • gle1l (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have inositol hexakisphosphate binding activity; phospholipid binding activity; and translation initiation factor binding activity. Involved in several processes, including epithelial cilium movement involved in determination of left/right asymmetry; neurogenesis; and poly(A)+ mRNA export from nucleus. Predicted to localize to cytoplasm and nuclear pore cytoplasmic filaments. Is expressed in several structures, including head; intestine; pectoral fin; pectoral fin bud; and trunk musculature. Used to study lethal congenital contracture syndrome 1. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gle1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lethal congenital contracture syndrome 1 Alliance Lethal congenital contracture syndrome 1 253310
Congenital arthrogryposis with anterior horn cell disease 611890
Associated With gle1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR012476 GLE1-like
Homologous_superfamily IPR038506 GLE1-like superfamily
Domain Details Per Protein
Protein Length GLE1-like GLE1-like superfamily
UniProtKB:B0S5D2 717
UniProtKB:B0S5C8 694
UniProtKB:Q6DRB1 695
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations