Gene
myo6a
- ID
- ZDB-GENE-040819-2
- Name
- myosin VIa
- Symbol
- myo6a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within blood vessel morphogenesis; inner ear development; and response to auditory stimulus. Predicted to be located in clathrin-coated pit; microvillus; and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3048 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16041 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23617 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43364 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myo6a | (3) | |
| CRISPR2-myo6a | (2) | |
| MO1-myo6a | N/A | Lanahan et al., 2010 |
| MO2-myo6a | N/A | Lanahan et al., 2010 |
| MO3-myo6a | N/A | Alkowari et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR032412 | Myosin VI, cargo binding domain |
| Domain | IPR036114 | Class VI myosin, motor domain |
| Domain | IPR049016 | Myosin VI, lever arm |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B757 | InterPro | 1278 | ||||||||
| UniProtKB:A0A8M9PBP4 | InterPro | 1150 | ||||||||
| UniProtKB:F1Q6Q6 | InterPro | 1253 | ||||||||
| UniProtKB:A0A8M9P2J2 | InterPro | 1153 | ||||||||
| UniProtKB:A0A8M3AL94 | InterPro | 1281 | ||||||||
| UniProtKB:A0A8M3AVX0 | InterPro | 1268 | ||||||||
| UniProtKB:A0A8M9PH95 | InterPro | 1288 | ||||||||
| UniProtKB:A0A8M3ASY2 | InterPro | 1256 | ||||||||
| UniProtKB:A0AB32T8A7 | InterPro | 1275 | ||||||||
| UniProtKB:A0AB32T911 | InterPro | 1265 | ||||||||
| UniProtKB:A0AB32TDX7 | InterPro | 1263 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-316K11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004111 (1) | 5012 nt | ||
| Genomic | GenBank:CU469066 (1) | 95331 nt | ||
| Polypeptide | UniProtKB:A0A8M9PH95 (1) | 1288 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Alkowari, M., Espino-Guarch, M., Daas, S., Abdelrahman, D., Hasan, W., Krishnamoorthy, N., Sathappan, A., Sheehan, P., Panhuys, N.V., The Qatar Genome Program Research Consortium, ., Estivill, X. (2022) Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients. International Journal of Molecular Sciences. 23(6):
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Carrington, B., Varshney, G.K., Burgess, S.M., Sood, R. (2015) CRISPR-STAT: an easy and reliable PCR-based method to evaluate target-specific sgRNA activity. Nucleic acids research. 43(22):e157
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Lanahan, A.A., Hermans, K., Claes, F., Kerley-Hamilton, J.S., Zhuang, Z.W., Giordano, F.J., Carmeliet, P., and Simons, M. (2010) VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis. Developmental Cell. 18(5):713-724
- Sittaramane, V., and Chandrasekhar, A. (2008) Expression of unconventional myosin genes during neuronal development in zebrafish. Gene expression patterns : GEP. 8(3):161-170
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