Gene

stat5b

ID
ZDB-GENE-040818-1
Name
signal transducer and activator of transcription 5b
Symbol
stat5b Nomenclature History
Previous Names
  • stat5.2
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; defense response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytosol and nucleus. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Huang et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stat5b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
growth hormone insensitivity syndrome with immune dysregulation 1 Alliance Growth hormone insensitivity with immune dysregulation 1, autosomal recessive 245590
growth hormone insensitivity syndrome with immune dysregulation 2 Alliance Growth hormone insensitivity with immune dysregulation 2, autosomal dominant 618985
Leukemia, acute promyelocytic, somatic 102578
Associated With stat5b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Domain IPR046994 STAT5a/5b, coiled-coil domain
Family IPR001217 Transcription factor STAT
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding domain superfamily SH2 domain SH2 domain superfamily STAT5a/5b, coiled-coil domain STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
UniProtKB:Q68SP2 787
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations