Gene

hpdb

ID
ZDB-GENE-040808-62
Name
4-hydroxyphenylpyruvate dioxygenase b
Symbol
hpdb Nomenclature History
Previous Names
  • hpd
  • zgc:92456
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including ectoderm; epidermis; median fin fold; neurons; and otic vesicle. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hpdb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hawkinsinuria Alliance Hawkinsinuria 140350
tyrosinemia type III Alliance Tyrosinemia, type III 276710
Associated With hpdb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
Domain IPR037523 Vicinal oxygen chelate (VOC) domain
Domain IPR041735 4-hydroxyphenylpyruvate dioxygenase, C-terminal
Domain IPR041736 4-hydroxyphenylpyruvate dioxygenase, N-terminal
Family IPR005956 4-hydroxyphenylpyruvate dioxygenase
Homologous_superfamily IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Domain Details Per Protein
Protein Length 4-hydroxyphenylpyruvate dioxygenase 4-hydroxyphenylpyruvate dioxygenase, C-terminal 4-hydroxyphenylpyruvate dioxygenase, N-terminal Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/fosfomycin resistance/dioxygenase domain Vicinal oxygen chelate (VOC) domain
UniProtKB:Q6AZV8 393
UniProtKB:A0A2R8RM25 385
UniProtKB:F1Q986 393
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations