Gene
acsl1b
- ID
- ZDB-GENE-040801-88
- Name
- acyl-CoA synthetase long chain family member 1b
- Symbol
- acsl1b Nomenclature History
- Previous Names
-
- zgc:101071 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and very long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including cardiovascular system; neurogenic placode; peripheral olfactory organ; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153172 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14420 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain | Long-chain fatty acid CoA synthetase, eukaryotic |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DEJ3 | InterPro | 697 | ||||
| UniProtKB:F1QDA6 | InterPro | 697 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl1b-201
(1)
|
Ensembl | 2,368 nt | ||
| mRNA |
acsl1b-202
(1)
|
Ensembl | 7,364 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-208H1 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7153172 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:101071 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003569 (1) | 2304 nt | ||
| Genomic | GenBank:CU462913 (1) | 101884 nt | ||
| Polypeptide | UniProtKB:F1QDA6 (1) | 697 aa |
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Yang, H., Huang, Y., Li, Z., Guo, Y., Li, S., Huang, H., Yang, X., Li, G., Chen, H. (2022) Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Animals : an open access journal from MDPI. 12(20):
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Sun, S.X., Wu, J.L., Lv, H.B., Zhang, H.Y., Zhang, J., Limbu, S.M., Qiao, F., Chen, L.Q., Yang, Y., Zhang, M.L., Du, Z.Y. (2020) Environmental estrogen exposure converts lipid metabolism in male fish to a female pattern mediated by AMPK and mTOR signaling pathways. Journal of hazardous materials. 394:122537
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Quinlivan, V.H., Farber, S.A. (2017) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Frontiers in endocrinology. 8:319
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