Gene
sfxn1
- ID
- ZDB-GENE-040801-45
- Name
- sideroflexin 1
- Symbol
- sfxn1 Nomenclature History
- Previous Names
-
- zgc:100851
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane transporter activity. Acts upstream of or within hemoglobin biosynthetic process and nucleate erythrocyte maturation. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in blood; head; nervous system; pronephric duct; and yolk syncytial layer. Orthologous to human SFXN1 (sideroflexin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140188 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Bao et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sfxn1 | Bao et al., 2021 | |
| MO1-sfxn1 | N/A | Bao et al., 2021 |
| MO2-sfxn1 | N/A | Bao et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004686 | Tricarboxylate/iron carrier |
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Domain Details Per Protein
| Protein | Length | Tricarboxylate/iron carrier |
|---|---|---|
|
UniProtKB:Q6DC00
|
322 | |
|
UniProtKB:F1R5W5
|
322 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-121D2 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-353O20 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7140188 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:100851 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003537 (1) | 1776 nt | ||
| Genomic | GenBank:CR855307 (1) | 167962 nt | ||
| Polypeptide | UniProtKB:F1R5W5 (1) | 322 aa |
No data available
- Bao, B., An, W., Lu, Q., Wang, Y., Lu, Z., Tu, J., Zhang, H., Duan, Y., Yuan, W., Zhu, X., Jia, H. (2021) Sfxn1 is essential for erythrocyte maturation via facilitating hemoglobin production in zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1867(5):166096
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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