Gene
traf3
- ID
- ZDB-GENE-040801-257
- Name
- TNF receptor-associated factor 3
- Symbol
- traf3 Nomenclature History
- Previous Names
-
- zgc:92367 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity. Acts upstream of or within response to yeast. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 132A and immunodeficiency 132B. Orthologous to human TRAF3 (TNF receptor associated factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92367 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 132A | Alliance | Immunodeficiency 132A | 614849 |
| immunodeficiency 132B | Alliance | Immunodeficiency 132B | 621096 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001293 | Zinc finger, TRAF-type |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR027128 | TNF receptor-associated factor 3, C3HC3D-type RING zinc finger |
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Domain Details Per Protein
| Protein | Additional Resources | Length | MATH/TRAF domain | TNF receptor-associated factor 3/5, RING domain | TNF receptor-associated factor 3, C3HC3D-type RING zinc finger | TNF receptor-associated factor 3, MATH domain | TNF receptor-associated factor TRAF, metazoa | TRAF1-6, MATH domain | TRAF-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DEG0 | InterPro | 573 | |||||||||||
| UniProtKB:A0A8M9PKN5 | InterPro | 546 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28G23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-154L10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92367 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003513 (1) | 2395 nt | ||
| Genomic | GenBank:BX511189 (2) | 223248 nt | ||
| Polypeptide | UniProtKB:Q6DEG0 (1) | 573 aa |
- Madushani, K.P., Shanaka, K.A.S.N., Jung, S., Kim, M.J., Lee, J. (2023) Ablation of myd88 alters the immune gene expression and immune cell recruitment during VHSV infection in zebrafish. Fish & shellfish immunology. 141:109006
- Shang, S., He, D., Liu, C., Bao, X., Han, S., Wang, L. (2023) TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus. Microbiology spectrum. 12(1):e0269923
- Liu, W., Jin, Y., Zhang, W., Xiang, Y., Jia, P., Yi, M., Jia, K. (2020) MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination. Viruses. 12(3):
- Jin, Y., Jia, K., Zhang, W., Xiang, Y., Jia, P., Liu, W., Yi, M. (2019) Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination. Frontiers in immunology. 10:2805
- Lai, Y., Liang, M., Hu, ., Zeng, Z., Lin, H., Yi, G., Li, M., Liu, Z. (2018) RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I. Fish & shellfish immunology. 86:474-479
- Zhang, W., Jia, P., Liu, W., Li, Y., Yi, M., Jia, K. (2018) Functional characterization of tumor necrosis factor receptor-associated factor 3 of sea perch (Lateolabrax japonicas) in innate immune. Fish & shellfish immunology. 75:1-7
- Srivastava, N., Shelly, A., Kumar, M., Pant, A., Das, B., Majumdar, T., Mazumder, S. (2017) Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish.. Cell death discovery. 3:17067
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
- He, B.L., Yuan, J.M., Yang, L.Y., Xie, J.F., Weng, S.P., Yu, X.Q., and He, J.G. (2012) The Viral TRAF Protein (ORF111L) from Infectious Spleen and Kidney Necrosis Virus Interacts with TRADD and Induces Caspase 8-mediated Apoptosis. PLoS One. 7(5):e37001
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