Gene

c8a

ID
ZDB-GENE-040801-239
Name
complement component 8, alpha polypeptide
Symbol
c8a Nomenclature History
Previous Names
  • zgc:92465 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to be involved in complement activation. Predicted to localize to membrane attack complex. Is expressed in chondrocranium; cleithrum; and liver. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c8a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type I complement component 8 deficiency Alliance C8 deficiency, type I 613790
Associated With c8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020863 Membrane attack complex component/perforin domain, conserved site
Domain IPR000742 EGF-like domain
Domain IPR020864 Membrane attack complex component/perforin (MACPF) domain
Family IPR001862 Membrane attack complex component/perforin/complement C9
Family IPR037565 Complement component C8 alpha chain
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Complement component C8 alpha chain EGF-like domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A repeat Membrane attack complex component/perforin/complement C9 Membrane attack complex component/perforin domain, conserved site Membrane attack complex component/perforin (MACPF) domain Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A0B5JS95 297
UniProtKB:Q6DBQ7 478
UniProtKB:F1Q6F3 592
UniProtKB:F1R901 478
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations