Gene
prkacab
- ID
- ZDB-GENE-040801-208
- Name
- protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
- Symbol
- prkacab Nomenclature History
- Previous Names
-
- zgc:91856
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; cAMP-dependent protein kinase activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; hypertrophic cardiomyopathy; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease. Is expressed in central nervous system; pronephric duct; and retinal ganglion cell layer. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91856 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pigmented nodular adrenocortical disease 4 | Alliance | Cushing syndrome, ACTH-independent adrenal, somatic | 615830 |
| Cardioacrofacial dysplasia 1 | 619142 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Family | IPR044109 | cAMP-dependent protein kinase catalytic subunit |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | cAMP-dependent protein kinase catalytic subunit | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DBV8
|
351 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkacab-201
(1)
|
Ensembl | 2,666 nt |
Interactions and Pathways
No data available
Plasmids
No data available