Gene

ctps1b

ID

ZDB-GENE-040801-160

Name

CTP synthase 1b

Symbol

ctps1b Nomenclature History

Previous Names

ctpsb
zgc:100914

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have CTP synthase activity and identical protein binding activity. Involved in notochord development. Predicted to localize to cytoophidium and cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in blood cell and vascular endothelium. Orthologous to several human genes including CTPS1 (CTP synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Cannon et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Dzaki et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctps1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 24	Alliance	Immunodeficiency 24	615897

Associated With ctps1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017456	CTP synthase, N-terminal
Domain	IPR017926	Glutamine amidotransferase
Domain	IPR033828	CTP synthase GATase domain
Family	IPR004468	CTP synthase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029062	Class I glutamine amidotransferase-like

Domain Details Per Protein

Protein	Length	Class I glutamine amidotransferase-like	CTP synthase	CTP synthase GATase domain	CTP synthase, N-terminal	Glutamine amidotransferase	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A9JT21 InterPro	589

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ctps1b-204 (1) Ensembl	Ensembl	2,008 nt	Select Tool ZFIN BLAST
mRNA	ctps1b-205 (1) Ensembl	Ensembl	2,026 nt	Select Tool ZFIN BLAST
ncRNA	ctps1b-002 (1) Ensembl	Ensembl	2,082 nt	Select Tool ZFIN BLAST
ncRNA	ctps1b-003 (1) Ensembl	Ensembl	494 nt	Select Tool ZFIN BLAST
ncRNA	ctps1b-004 (1) Ensembl	Ensembl	821 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations