Gene
glrbb
- ID
- ZDB-GENE-040801-106
- Name
- glycine receptor, beta b
- Symbol
- glrbb Nomenclature History
- Previous Names
-
- glrb2 (1)
- bandoneon
- beo
- zgc:101041
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables extracellularly glycine-gated chloride channel activity. Acts upstream of or within protein localization. Predicted to be located in postsynaptic membrane. Is expressed in hindbrain and spinal cord. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperekplexia 2 | Alliance | Hyperekplexia 2 | 614619 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Domain | IPR047029 | Glycine receptor subunit beta, transmembrane domain |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
| Family | IPR008060 | Glycine receptor beta |
| Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
| Homologous_superfamily | IPR038050 | Neuronal acetylcholine receptor |
Domain Details Per Protein
| Protein | Length | Glycine receptor beta | Glycine receptor subunit beta, transmembrane domain | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DC22
|
494 | |||||||||
|
UniProtKB:A0A8M9QB01
|
502 | |||||||||
|
UniProtKB:A0A8M2B3E0
|
266 |
Interactions and Pathways
No data available
Plasmids
No data available